Original scientific paper

https://doi.org/10.20471/acc.2017.56.01.14

The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls

Aleksandra Klisić orcid.org/0000-0001-7870-0996 ; Primary Health Care Center, Podgorica, Montenegro
Nebojša Kavarić orcid.org/0000-0002-4658-9960 ; Primary Health Care Center, Podgorica, Montenegro
Bojko Bjelaković orcid.org/0000-0002-7879-5793 ; Clinical Department of Pediatrics, School of Medicine, University of Niš, Niš
Ivan Soldatović orcid.org/0000-0003-4893-1683 ; Institute for Biostatistics, Medical Informatics and Research in Medicine, School of Medicine, University of Belgrade, Belgrade, Serbia
Milica Martinović ; Department for Pathophysiology and Laboratory Medicine, School of Medicine, University of Montenegro, Podgorica, Montenegro
Jelena Kotur-Stevuljević orcid.org/0000-0002-6980-3069 ; Department of Medical Biochemistry, School of Pharmacy, University of Belgrade, Belgrade, Serbia

Abstract

Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge,there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Th erefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6±1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2≤ CVRS ≤1, 2≤ CVRS ≤4 and CVRS ≥5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p<0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R2=0.342, p<0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.

Keywords

Adolescents; Cardiovascular diseases; Risk; Obesity; Retinol-binding protein 4

Hrčak ID:

184345

URI

https://hrcak.srce.hr/184345

Publication date:

1.3.2017.

Article data in other languages: croatian

Visits: 2.326 *