Review article

https://doi.org/10.21860/medflum2017_182951

Pathohistological diagnosis of prostate cancer

Gordana Đorđević ; Zavod za opću patologiju i patološku anatomiju, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Sanja Štifter ; Zavod za opću patologiju i patološku anatomiju, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Christophe Štemberger ; Zavod za opću patologiju i patološku anatomiju, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska

Abstract

Prostate cancer (PCa) is the most common male cancer in Europe and the US. The early diagnosis relies on prostate specifc antigen serum test, digito-rectal and ultrasound examinaton. Definitve verificaton is pathohistological with individual assesment of aggressiveness of the tumor potental through prognostc parameters such as Gleason gradus/grade groups, percentage and number of affected cilinders in the biopsy, stage and positve margins in prostatectomy. These parameters signifcantly affect the choice and protocol of therapies but can not identfy a localized, clinically signifcant cancer that will certainly cause metastatc disease and require treatment. Therefore, researchers focused on molecular biomarkers that are important in prognosis, pathogenesis, and as a target molecules for possible therapy. The article contributes to a better understanding of the pathohistological findings and new facts about the molecular pathogenesis of tumors, which are important for the care of patients with prostate cancer.

Keywords

molecular biomarkers; prognostic factors; prostate cancer

Hrčak ID:

184827

URI

https://hrcak.srce.hr/184827

Publication date:

1.9.2017.

Article data in other languages: croatian

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