Medicina Fluminensis, Vol. 53 No. 3, 2017.
Review article
https://doi.org/10.21860/medflum2017_182973
Experimental models of kidney transplantation: Possibilities to explore new approaches
Josip Španjol
; Klinika za urologiju, KBC Rijeka, Katedra za urologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Klara Smolić
; Klinika za urologiju, KBC Rijeka, Katedra za urologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Abstract
Today’s clinical practice and research are based on alo- (homo) transplantation. The most common organ used in transplant medicine is certainly the kidney. Kidney transplantation is ingrained, the best and most economical way to treat chronic renal failure. Animal models are necessary for research in the field of organ transplantation. The most commonly used animal in the study of kidney transplantation is a rat. In modern studies of kidney transplantation, we have two well-known animal models: the rat model of chronic renal failure and the rat model of kidney transplantation. To operate on experimental animal’s researcher must possess an international certificate. Growing, euthanasia procedures, postoperative analgesia, breeding, animal housing (temperature, food, etc.), as well as the disposal of animal carcasses and tissues are highly standardized. Most of the current researches, as well as those that will take place over the next few years have in focus the damage caused by warm and cold ischemia. To avoid the biopsy of the transplanted kidney studies will be directed towards the development of noninvasive methods for early detection of transplant rejection such as contrast ultrasound or serum markers of acute rejection of the transplanted kidney. In addition, all kinds of investigations will address the cultivation of viable organs for transplantation using stem cells. In conclusion it is clear that different animal models of kidney transplantation will play an important role in future researches in order to increase the number of transplants as well as the prolongation of the survival of transplanted organs.
Keywords
animal models; immunomodulation; kidney transplantation; rat model; transplant rejection
Hrčak ID:
184842
URI
Publication date:
1.9.2017.
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