Original scientific paper

https://doi.org/10.1515/acph-2017-0036

Alkyl polyglucoside vs. ethoxylated surfactant- based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

NATAŠA Z. BUBIĆ PAJIĆ ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina
MARIJA N. TODOSIJEVIĆ ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
GORDANA M. VULETA ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
NEBOJŠA D. CEKIĆ ; Faculty of Technology, University of Niš, 16000 Leskovac, Serbia; DCP Hemigal, 16000 Leskovac, Serbia
VLADIMIR D. DOBRIČIĆ ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
SONJA R. VUČEN ; School of Pharmacy, University College Cork, Cork, Ireland
BOJAN R. ČALIJA ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
MILICA Ž. LUKIĆ ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
TANJA M. ILIĆ ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
SNEŽANA D. SAVIĆ ; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia

Abstract

Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.

Keywords

alkyl polyglucoside; ethoxylated surfactant; adapalene; sertaconazole nitrate; biocompatible microemulsion; in vivo skin irritation

Hrčak ID:

186507

URI

https://hrcak.srce.hr/186507

Publication date:

31.12.2017.

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