Original scientific paper

Formation of Isopenillic Acid Derivatives in the Reaction of Benzylpenicillin with Phosphorus Pentachloride

M. Kovačević ; Research Institute PLlVA, Zagreb, Croatia, Yugoslavia
J. J . Herak ; Research Institute PLlVA, Zagreb, Croatia, Yugoslavia
B. Gašpert ; Research Institute PLlVA, Zagreb, Croatia, Yugoslavia

Abstract

Treatment of benzylpenicillin ester (I) with phosphorus pentachloride
at 60 °c gives a mixture of benzylisopenillic acid ester (II)
and its disulphide (Ill). Under the same reaction conditions, 6-
-phthalimidopenicillinate ester (V) yields a-methyl 6-phthalimido- ·
penicilloate ester (VIII).

Keywords

Hrčak ID:

194325

URI

https://hrcak.srce.hr/194325

Publication date:

31.12.1981.

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