Original scientific paper

ESR Study of the Reaction Sites in the Barbituric Acid Derivatives

J. N. Herak ; Institute »Ruder Boskovic«, 41000 Zagreb, Croatia, Yugoslavia
J. J. Herak ; Institute »Ruder Boskovic«, 41000 Zagreb, Croatia, Yugoslavia

Abstract

ESR spectroscopy has been used to analyse free radicals in
the barbituric acid derivatives exposed to thermal H atoms or to
excited Ar atoms. Reaction with both types of atoms leads to the
same products, demonstrating that the most probable reaction sites
in these molecules do not depend upon whether the chemicai or
physicai type of energy is transferred to the molecules. In all the
barbituric acid derivatives studied the reaction takes place at the
5-substituent of the compound. The reaction observed is either the
loss of the substituent or a change in the substituent. The former
reaction is observed in the pharmacologically inactive barbituric
acid derivatives, the latter in the active ones.

Keywords

Hrčak ID:

197191

URI

https://hrcak.srce.hr/197191

Publication date:

20.3.1973.

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