Reumatizam, Vol. 65 No. 1, 2018.
Professional paper
CLINICAL FEATURES OF MALIGNANCIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A 10-YEAR DATA FROM UNIVERSITY HOSPITAL SPLIT
Antonija Vuković
Dijana Perković
Marin Petrić
Daniela Marasović Krstulović
Mislav Radić
Dušanka Martinović Kaliterna
Abstract
Objectives: Th e aim of this study was to determine the clinical features of malignant neoplasms in patients with systemic lupus erythemtosus (SLE) treated at the University Hospital Split
Methods: All of the patients included in this study were suffering from SLE and were treated at the University Hospital Split during the period from January 1, 2007 to December 31, 2016. The data were collected from the archives of the Department of Clinical Immunology and Rheumatology.
Results: In a group of 271 patients, 24 developed a malignant neoplasm (8.85%), 3 of whom were male (12.50%) and 21 female (87.50%).We found 27 malignant neoplasms due to the fact that some patients had had more than one tumor. The patients suffering from SLE and malignant neoplasms were statistically significantly older than the patients suffering only from SLE (T=3.43; p<0.001). Most patients developed malignoma aft er the diagnosis of SLE (79.17%). The most common malignoma localization was the cervix (25%), followed by the thyroid gland (12.50 %), lungs (8.33 %), colon (8.33 %), and breast (8.33 %). According to the patohistological findings most of the patients had cancer (83.33%; p<0.001). Most of the patients in the malignoma group were ANA[ antinuclear antibody] (79.17%) and ENA [extractable nuclear antibody] (79.17%) positive. Th e majority of them were on glucocorticoid therapy (54.16%), followed by a combination of glucocorticoid and immunosuppressive therapy (29.16%).
Conclusion: Malignant diseases most commonly occur in eldery patients with SLE. In our study, the cervix was the most common localization of the malignoma. That differs from other studies, in which non-Hodgkin lymphoma was the most common finding. Most of the patients with malignoma and SLE were ANA and ENA positive.
Keywords
Lupus erythematosus, systemic; Neoplasms; Hospitals, university – statistics and numerical data; Incidence; Risk factors; Retrospective studies; Croatia
Hrčak ID:
207096
URI
Publication date:
16.10.2018.
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