Review article

https://doi.org/10.24141/1/4/2/12

Oncolytic Viruses

Ines Poljak ; University of Applied Health Sciences, Zagreb
Petra Korać orcid.org/0000-0003-4783-2114 ; Division of Molecular Biology, Department of Biology, Faculty of Science of the University of Zagreb, Zagreb, Croatia

Abstract

Malignant tumors are the most common cause of mortality in humans. Accumulation of mutation in cells causes uncontrolled cell division as well as prevention of their programmed cell death, leading to neoplastic changes. Tumor mass which avoids the immune response of the host, grows and spreads. Modern approach to malignant tumor therapy, which is still in the research stage, is based on the use of genetically modified bacteria and/or viruses. They are used for promotion of the chemotactic effect or production of the receptors that will be recognized by the immune system of the host and in this way stimulate the effector part of the body’s defense system to destroy the tumor mass. This paper summarizes the most recent methods in the field.
Keywords:

Keywords

genetic engineering; oncolytic viruses; malignant tumor

Hrčak ID:

207820

URI

https://hrcak.srce.hr/207820

Publication date:

30.10.2018.

Article data in other languages: croatian

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