Short communication, Note

In vitro and in vivo Reactivation of Cholinesterases Inhibited by Highly Toxic Organophosphorus Compounds

M. Maksimović ; High Military Technical School, Zagreb, Yugoslavia
B. Bošković ; High Military Technical School, Zagreb, Yugoslavia
Z . Binenfeld ; High Military Technical School, Zagreb, Yugoslavia

Abstract

The in vitro and in vivo reactivating power of 1,3-acetone-
bis-(4-hydroxyiminoformyl pyridinium) dibromide (MBM-3) was
compared with that of 1,3-trjmethylene~bis-(4-hydroxyjminoformyl
pynidinium) dibromide (TMB-4) and 1,3-dimethylether-bis-(4-hydroxyiminoformyl pyridinium) dibromide (Toxogonin). As a source of
choli'nesterase rat's whole blood, plasma, erythrocytes, and brain ho~
mogenate, were u sed. The cholinesterase inhibition was performed
by ethyl N-dimethylaminophosphorocyanidate (Taibun); ethyl 4-
-nitrophenyl phosphonate (Armin), 0,0-diethyl-S-(2-diethylaminoethyl)
phosphorothioate (Amitone-3); pinacolyl-methyl-phosphorofluoridate
(Soman); and O-ethyl-S-(2-diethylamino ethyl phosphorothioate
(Edemo-3).

Keywords

Hrčak ID:

208048

URI

https://hrcak.srce.hr/208048

Publication date:

25.10.1968.

Visits: 717 *