Original scientific paper

https://doi.org/10.2478/acph-2019-0022

Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in-vitro release, and mucoadhesive strength

AMIRA A. RASHAD ; Mepaco-Medifood Pharmaceutical Company, El Sharkia, Egypt
SARA NAGEEB EL-HELALY orcid.org/0000-0001-6382-0995 ; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
RANDA T. ABD EL REHIM ; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
OMAIMA N. EL-GAZAYERLY ; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Abstract

Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup buccoadhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors showed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953.

Keywords

azelnidipine, liquisol; core-in-cup; buccoadhesive tablets; tablet micromeritics; in vitro release

Hrčak ID:

216137

URI

https://hrcak.srce.hr/216137

Publication date:

30.9.2019.

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