Review article

https://doi.org/10.21860/medflum2019_218802

Nonsteroidal antiinflammatory drugs and treatment of cystoid macular edema

Marijana Bilen Babić orcid.org/0000-0003-3853-6794 ; Department of Ophthalmology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Maja Merlak ; Department of Ophthalmology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Renata Gržetić-Lenac ; Department of Ophthalmology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Ivana Valković Antić ; Department of Ophthalmology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Petra Grubešić ; Department of Ophthalmology, Clinical Hospital Center Rijeka, Rijeka, Croatia

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) have become a significant therapeutic adjunctive tool in the routine and complicated intraocular surgery. Topical NSAIDs prevent intraoperative miosis, reduce pain, postoperative inflammation and incidence of cystoid macular edema (CME). Although there is no established protocol for prophylaxis of pseudophakic CME, due to the relationship between proinflammatory prostaglandins and CME, using corticosteroids and NSAIDs could prevent CME. NSAIDs have a synergistic antiinflammatory effect with steroids, but can also be used alone when corticosteroid therapy could be harmful. Prospective clinical trials need to define treatment protocol for topical NSAIDs use, due to their powerful influence to prevent perioperative complications.

Keywords

cataract; cyclooxygenase inhibitors; macular edema; prostaglandins

Hrčak ID:

218802

URI

https://hrcak.srce.hr/218802

Publication date:

1.6.2019.

Article data in other languages: croatian

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