Original scientific paper

https://doi.org/10.20471/acc.2019.58.01.09

Noninvasive Tear Film Break-Up Time Assessment Using Handheld Lipid Layer Examination Instrument

Sania Vidas Pauk orcid.org/0000-0002-8229-7826 ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Igor Petriček ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Tomislav Jukić ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Smiljka Popović-Suić ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Martina Tomić ; Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia
Miro Kalauz ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Sonja Jandroković ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia
Sanja Masnec ; Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia

Abstract

The aim was to determine feasibility and reliability of noninvasive tear break-up time (NIBUT) assessment using handheld lipid layer examination instrument, and to compare it with standard tear break-up time (TBUT) test. Fifty patients were enrolled, 31 with and 19 without dry eye symptoms. Schein questionnaire was used to assess dry eye symptoms. During examination, three NIBUT measurements were performed on each eye using handheld instrument, followed by three TBUT measurements. Receiver operating characteristic curves, sensitivity, specificity and logistic regression analysis were generated. Median NIBUT values were significantly shorter in dry eye symptom
group than in control group in all three measurements (9, 8 and 8 s vs. 21, 22 and 21 s; p<0.001). TBUT values showed no significant difference between the groups in the first measurement (p=0.053),
but the values were significantly shorter in dry eye symptom group in second and third measurements (p=0.020). The cutoff value to distinguish patients with symptoms of dry eye from control group was
12 seconds for NIBUT and 8 seconds for TBUT, with NIBUT having significantly higher sensitivity, specificity, area under the receiver operating characteristic curve and positive predictive value. NIBUT,
measured by handheld lipid layer examination instrument, was superior to TBUT in detecting dry eye.

Keywords

Cornea; Tears; Surveys and questionnaires; Dry eye syndrome – diagnosis

Hrčak ID:

220565

URI

https://hrcak.srce.hr/220565

Publication date:

1.3.2019.

Article data in other languages: croatian

Visits: 3.387 *