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Liječnički vjesnik, Vol. 141 No. suppl.1, 2019.

Meeting abstract

Pentadecapeptide BPC 157 Counteracts Hypertension and Compromised Optic Disc Circulation and Following Atrophy in Rats Subjected to High Fructose Diet

Filip Radevski ; Department of Pharmacology, School of Medicine, University of Zagreb
Tajana Đurašin ; Department of Pharmacology, School of Medicine, University of Zagreb
Pavla Peraić ; Department of Pharmacology, School of Medicine, University of Zagreb
Marko Belamarić ; Department of Pharmacology, School of Medicine, University of Zagreb
Hrvoje Vraneš ; Department of Pharmacology, School of Medicine, University of Zagreb
Marko Antunović ; Department of Pharmacology, School of Medicine, University of Zagreb
Ivan Krezić ; Department of Pharmacology, School of Medicine, University of Zagreb

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Abstract

INTRODUCTION We sought to determine whether stable gastric pentadecapeptide BPC 157 in rats subjected to a high fructose diet counteracts hypertension and compromised optic disc circulation and following atrophy. METHODS: Rats were put on a high fructose (80%) diet during a 1 month period. The treated group received BPC 157 in drinking water (10 ng/kg/rat/day). Their blood pressure was regularly measured, and they were subjected to ocular fundus examination. RESULTS At the end of the 1 month period, in control rats, with a mean blood pressure of 146 mmHg, we observed a pale optic disc with well-defined outer borders. In addition, the excavation noticed suggests compromised optic disc circulation and atrophy. Very thin arteries and thick hyperemic veins appeared, resulting in an arterial/vein diameter ratio of about 1/4. An abnormal red reflex and reduced brightness from the choroid suggests a decreased blood flow and choroidal blood filling. Contrarily, in the treated group of rats, who presented with a mean blood pressure of about 132 mmHg, all these changes were significantly attenuated. The optic disc appeared more vivid and healthier with less compromised circulation, and the arterial/vein diameter ratio was about 3/4. The choroid in rats drinking BPC 157 was brighter and with a more pronounced shade of red. CONCLUSION BPC 157 may be considered for treating hypertension, particularly when vascular obstruction is present.

Keywords

BPC; hypertension; retinopathy; rats

Hrčak ID:

221910

URI

https://hrcak.srce.hr/221910

Publication date:

9.4.2019.

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