Original scientific paper

https://doi.org/10.2478/acph-2020-0030

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

BLAŽ GRILC ; University of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000 Ljubljana, Slovenia
JURIJ ZDOVC ; University of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000 Ljubljana, Slovenia
ODON PLANINŠEK ; University of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000 Ljubljana, Slovenia

Abstract

Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. This system extends the release time and enables more detailed sample discrimination according to formulation. It could be used as a tool for in vivo prediction of drug release rates from buccal film formulations. The flow cell contains two chambers separated by a membrane through which the released active pharmaceutical ingredient is measured. Vital system variables and their effects on the release rate of the model active pharmaceutical ingredient are presented for formulations based on sodium alginate polymer. The method reflects the differences between films and is shown to be discriminatory for evaluation of buccal formulations.

Keywords

release rate; buccal films; hydrostatic pressure; flow cell

Hrčak ID:

227177

URI

https://hrcak.srce.hr/227177

Publication date:

30.9.2020.

Visits: 1.373 *