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Acta clinica Croatica, Vol. 59. No. 2., 2020.

Original scientific paper

https://doi.org/10.20471/acc.2020.59.02.04

The Effect of Atorvastatin on the Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke

Mojtaba Khazaei ; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Mozhdeh Khosravi ; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Shahir Mazaheri ; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Mehrdokht Mazdeh ; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Masoud Ghiasian ; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Taheri orcid id orcid.org/0000-0001-8381-0591 ; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Soudeh Ghafouri-Fard ; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Abstract

Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of oneyear treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured by extracranial Doppler ultrasonography in the distal part of the common carotid artery at the beginning of the study, at 6 months and one year of treatment with atorvastatin. The IMT of both right and left carotid arteries decreased after 6- and 12-month atorvastatin treatment. Based on the results of this study, long-term administration of atorvastatin was associated
with reduction in carotid artery IMT in patients with ischemic stroke. Such a decrease in IMT may prevent subsequent stroke or cardiovascular events in these patients.

Keywords

Intima-media thickness; Common carotid artery; Atorvastatin; Stroke

Hrčak ID:

243553

URI

https://hrcak.srce.hr/243553

Publication date:

1.6.2020.

Article data in other languages: croatian

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