Review article
Myocardial effects of cardiac arrest and resuscitation with especial reference to mitochondrial injury
RAÚL J. GAZMURI
orcid.org/0000-0002-3848-7227
; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center, Chicago, USA
IYAD M. AYOUB
; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center, Chicago, USA
JEEJABAI RADHAKRISHNAN
; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center, Chicago, USA
Abstract
The underlying mechanism of cell injury during ischemia and reperfusion is complex and timesesnsitive. Some processess develop coincidentally with the onset of ischemia and during reperfusion leading to abnormalities in energy metabolism, acid base status, and intracellular ion homeostasis. Other processes develop later and encompass activation of various signalling pathways that have deleterious or beneficial effects on specific effectors, but associated with sustained disruption of energy production contractile dysfunction and activation of apoptotic pathways. Discussion on the various cell mechanisms resposible for cell injury is beyond the scope of this review. However, pertinent to our discussion is the mounting evidence pointing to mitochondria as key target organelles of reperfusion injury.
Keywords
cardiac arrest; mitochondrial injury; cardiopulmonary resuscitation; apoptosis
Hrčak ID:
22521
URI
Publication date:
1.4.2008.
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