Croatica Chemica Acta, Vol. 31 No. 4, 1959.
Short communication, Note
A Route for the Preparation of L-Hygrinic Acid *
R. Marušić
; Chemical Laboratory, Faculty of Science, University of Z agreb Strossmayerov trg 14, Zagreb, Croatia, Yugoslavia
Abstract
Hygrinic acid was first obtained by the oxidation of hygrine with chromic acid. Later Karrer and Widmer obtained L-hygrinic acid by oxidation of N-methyl-nicotone with chromic acid. They determined the configuration of L-hygrinic acid by the permethylation to L-stachydrine obtained also through the permethylation of L-proline. In the present paper the preparation of L-hygrinic acid from L-proline is described. L-Proline is methylated according to the procedure of Sommelet and Ferrand and optically pure anhydrous L-hygrinic acid with a- 84° and Rf 0.37 is obtained.
Keywords
Hrčak ID:
244892
URI
Publication date:
8.4.1960.
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