Review article

https://doi.org/10.21860/medflum2020_245225

Epigenetic biomarkers in kidney transplantation

Klara Frančić ; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Nataša Katalinić ; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Sanja Balen ; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska

Abstract

Currently used prognostic biomarkers in kidney transplantation are – crossmatch, serum creatinine concentration and evaluation of glomerular filtration rate, proteinuria and a histopathological analysis of graft biopsy. The development of genetics and new technologies has enabled the discovery of new biomarkers as early predictors of acute rejection response, delayed graft function, ischemia-reperfusion injury, interstitial fibrosis, tubular atrophy and long-term graft survival. Numerous studies have been conducted to examine the influence of environmental factors on human genome and its relation with the immune response in kidney transplantation. The aim of this article is to present potential epigenetic biomarkers – the products of epigenetic mechanisms, and their importance in the outcome of renal transplantation.

Keywords

biomarkers; epigenetic processes; graft survival; renal transplantation

Hrčak ID:

245225

URI

https://hrcak.srce.hr/245225

Publication date:

1.12.2020.

Article data in other languages: croatian

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