Croatica Chemica Acta, Vol. 29 No. 3-4, 1957.
Original scientific paper
The Correlation of Configuration of Optically Active Nor-pseudo-ephedrine and Alanine
D. Fleš
; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
A. Markovac-Prpić
; Research Department, »Pliva« Pharmaceutical and ChemicaL Works, Zagreb, Croatia, Yugoslavia
Abstract
D-Nor - pseudo- ephedrine was prepare d from N-phthaloyl-D-alanyl chloride through the intermediate D-a-phthalimido-propiophenone which was reduced with aluminum isopropoxide to the appropriate carbinol. L-Nor- pseudo-ephedrine was prepared in the same way from L-alanine. The configurational correlation between D-nor-pseudo-ephedrine and D-alanine a nd L-nor- pseudo-ephedrine and L-alanine was established. The configurational relation of C(2) atom of chloramphenicol and D-(-)-nor - pseudo - ephedrine was thus established since chloramphenicol was previously synthetized from D-serine.
Keywords
Hrčak ID:
246040
URI
Publication date:
30.12.1957.
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