Original scientific paper

The Synthesis of 14C Labelled Serotonin/2-(5' -Hydroxyindolyl-3')-ethylamine-[l-14C]/

D. Keglević-Brovet ; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia
S. Kveder ; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia
S. Iskrić ; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia

Abstract

By modification of published procedure s on the 2-(indolyl)-3') ethylamines syntheses it' was possible to obtain 2-(5'-benzylox yindolyl-3')-acetonitrile-[1-14C) (III) in a 820/o yield, from equimolar amounts of 5-benzyloxygramine methosulphate (II) (1.1 mM) and sodium cyanide-UC (1.0 mM, 1 mC). III was reduced with lithium aluminium hydride to the corresponding amine IV, catalitically debenzylated to serotonin V and isolated as crea tinine sulphate complex VI in a 640/o yield (calc'd on Nat4CN), having a specific activity of 1.71 μC/mg. (0.69 mC/ mM).

Keywords

Hrčak ID:

246316

URI

https://hrcak.srce.hr/246316

Publication date:

30.12.1957.

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