Review article

https://doi.org/10.21860/medflum2021_365327

Inherited thrombophilia

Petra Baumgartner ; Klinika za bolesti srca i krvnih žila, KBC Rijeka, Rijeka, Hrvatska
Toni Valković ; Zavod za hematologiju, KBC Rijeka; Medicinski fakultet i Fakultet zdravstvenih studija Sveučilišta u Rijeci, Rijeka, Hrvatska

Abstract

The term thrombophilia implies inherited and/or acquired disorders of the hemostasis mechanism that predispose to the development of thrombosis. Inherited thrombophilia includes conditions in which an inherited genetic mutations affect the amount or function of proteins involved in the coagulation system, and as a consequence, an increased tendency to venous and, much less frequently, arterial thrombosis. Undoubtedly defined inherited thrombophilic conditions are the deficiency of antithrombin, protein C and protein S and the appearance of factor V Leiden and rothrombin's variants. There is still no clear recommendation for testing hereditary thrombophilia, and the prophylaxis and the treatment of thromboembolic events must be individualized.

Keywords

antithrombin; factor V Leiden; inherited thrombophilia; protein C; protein S; prothrombin variant; thromboembolic events

Hrčak ID:

251266

URI

https://hrcak.srce.hr/251266

Publication date:

1.3.2021.

Article data in other languages: croatian

Visits: 5.506 *