Review article
Acute and chronic side effects of corticosteroids used for treatment of neonatal conditions
Filip Juroš
; School of Medicine University of Zagreb
Maja Filipović-Grčić
; Department of Endocrinology, Diabetes and Metabolism Diseases “Mladen Sekso”, UHC “Sisters of Mercy” Zagreb
Boris Filipović-Grčić
; Department of Neonatology and Neonatal Intensive Care, Pediatric Clinic, UHC Zagreb, Faculty of Medicine, University of Zagreb;
Abstract
Prematurity is a large problem worldwide. Premature infants are at high risk of developing chronic lung disease (CLD). Corticosteroids (CS) have been proven efficient in improving lung function and facilitating weaning of premature infants with CLD from mechanical ventilation. On the other hand, their use has been related to severe short and long-term side effects. Over the years, CS have been widely used in many conditions in premature infants, but after a connection to severe side effects had been established, their use registered a large downfall, creating the perplexity whether to give CS or not. Clinicians may also be confused in deciding which synthetic CS to use and at what time, dose and duration. A difference in activity and side effects between dexamethasone (DEX) and hydrocortisone (HC) should thereby also be considered. This review describes acute and chronic side effects connected to CS and will attempt to shed light on how clinicians can minimize them.
Keywords
dexamethasone; hydrocortisone; neurodevelopment; newborn; side effects
Hrčak ID:
251858
URI
Publication date:
1.1.2018.
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