Original scientific paper

Genetic Frequencies of Paraoxonase 1 Gene Polymorphisms in Croatian Population

Marija Grdić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Karmela Barišić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Lada Rumora ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ilza Salamunić ; Split University Hospital, Split, Croatia
Milena Tadijanović ; »Dr. Josip Benčević« General Hospital, Slavonski Brod, Croatia
Tihana Žanić Grubišić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Renata Pšikalova ; Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
Zlata Flegar-Meštrić ; Merkur University Hospital, Zagreb, Croatia
Dubravka Juretić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Abstract

Paraoxonase 1 (PON1), a HDL-associated enzyme, is believed to contribute to the protective effects of HDL by decreasing the generation of lipid peroxidation products during the process of LDL oxidation. It has been reported that polymorphisms in promoter and coding regions of the pon1 gene could affect PON1 activity. The aim of this study was to determine the frequencies of pon1 polymorphisms Q192R, L55M and –108C>T and their influence on PON1 activity in healthy population of Croatia. The following genotype frequencies were determined: 60 % QQ, 34 % QR, 6 % RR for Q192R; 44 % LL, 43 % LM, 13 % MM for L55M; 30 % CC, 48 % CT, 22 % TT for –108C>T polymorphism. Genotypes RR, LL and CC were found to be associated with higher PON1 activity. The most frequent genotypes in healthy Croatian population were QQ, CT and equally present LL and LM.

Keywords

paraoxonase 1; polymorphisms; Croatian population

Hrčak ID:

23398

URI

https://hrcak.srce.hr/23398

Publication date:

15.4.2008.

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