Review article
THE PATHOGENETIC MECHANISM IN DELAYED ONSET MUSCLE SORENES
Jagoda Ravlić-Gulan
; Department of Pfysiology and Immunology, Scool of medicine, University of Rijeka, Croatia
Tea Schnurrer-Luke Vrbanić
; Clinic for Orthopedics lovran, School of medicine, Universiy of Rijeka, Croatia
Vladimir Boschi
; Department of Traumatology, Cincal hospital center Split, Croatua
Matjaž Vogrin
; Department of Orthopedics, Clinical Hospital center Maribor, Slovenia
Abstract
SUMMARY
Delayed onset muscle soreness (DOMS) is the feeling of
pain, tenderness, deep ache and stiffness that usually
develops 24-48 hours after an unaccustomed or a high
intensity exercise and subsides generally within 5 to 7
days. Despite numerous studies there is no general consensus
on the underlying mechanisms of DOMS, treatment
or prevention strategies. A major causative factor is
eccentric muscle actions, i.e. active resistance to muscle
lengthening. However, the cellular basis for this response
remains unclear. Eccentric activities induce micro-injury
of muscle cells resulting in myofibrillar disruption, prolonged
loss of muscle strength, decrements in motor control,
changes in energy substrate levels and presence of
muscle proteins in the blood. Some recent research claims
that DOMS is not caused by the pain from damaged
muscle cells and secondary induced inflammatory processes,
but from the reinforcement process. The biological
response of muscle to eccentric contractions results in
strengthening and protection from further injury. The
muscle responds to training by reinforcing itself up to
and above its previous strength by adding new sarcomeres,
the segments in the muscle fibrils (sarcomerogenesis).
In this review, we summarize the muscle cell disturbances
and adaptation processes known to be involved in
pathogenetic mechanisms of DOMS which could be of
clinical importance in sports medicine.
Keywords
delayed onset muscle soreness; eccentric contraction; sarcomerogenesis
Hrčak ID:
23419
URI
Publication date:
20.9.2007.
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