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Psychiatria Danubina, Vol. 29 No. suppl. 3, 2017.

Conference paper

DOES NEUROGENESIS RELATE TO DEPRESSION AND DO ANTIDEPRESSANTS AFFECT NEUROGENESIS?”

Ada Maria Krzak ; Clare College Cambridge, Cambridge, UK
Jenny Jia Ling Cao ; Clare College Cambridge, Cambridge, UK
Mark Agius ; Clare College Cambridge, Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK
Cyril Hoschl ; National Institute of Mental Health, Czech Republic

Full text: english pdf 155 Kb

page 241-246

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Abstract

Depression is characterized by atrophy in several brain structures, with the hippocampus seemingly particularly affected. A wide
variety of cellular mechanisms have been proposed for these structural modifications, including the regression of dendritic
branching. While neurogenesis alone appears inadequate to produce such marked changes, an altered rate is likely to affect
hippocampal function. There is also strong evidence for neurotransmitter and glucocorticoid-mediated effects on neurogenesis,
providing routes for the action of antidepressants. We aim to show how neurogenesis relates to the ‘conventional monoaminergic theory of depression’ and its modulation by antidepressants.

Keywords

depression; neurogenesis; neurotransmitters; glucocorticoids; trophic factors

Hrčak ID:

263806

URI

https://hrcak.srce.hr/263806

Publication date:

15.6.2017.

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