Conference paper

DIFFUSION-WEIGHTED IMAGING OF THE BRAIN IN BIPOLAR DISORDER: A CASE REPORT

Monika Czarnowska-Cubała ; 1st Department of Radiology, Medical University of Gdańsk, Gdańsk, Poland
Mariusz S. Wiglusz ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Wiesław Jerzy Cubała ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Jerzy Landowski ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Krzysztof Krysta ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland

Abstract

Background: Some investigations strongly support a role of glial abnormalities in the pathophysiology of bipolar disorder. The
degree of white matter axonal and myelination disruption is measured through the rate of water molecule diffusion. High ADC
measures correspond to relatively unimpeded water diffusion, while low ADC measures reflect preserved myelinated axons.
Case report: Parietal and occipital areas may be involved in the pathophysiology of bipolar disorder, particularly in cognition
and perception, along with the prefrontal and temporal cortices for the disruption of emotional processing. In the literature the
widespread alterations of the cortical white matter microstructure is documented.
Conclusions: This case reports demonstrates the features of the increased mean ADC values in the left occipital lobe. Future
DWI studies are expected to investigate the correlation of white matter changes with the functional impairment, which often persists
during euthymia in bipolar disorder.

Keywords

DWI; bipolar disorder; neuroimaging

Hrčak ID:

264487

URI

https://hrcak.srce.hr/264487

Publication date:

8.9.2015.

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