Conference paper

RAPID-ONSET AGRANULOCYTOSIS IN A PATIENT TREATED WITH CLOZAPINE AND LAMOTRIGINE

Anna Emilia Urban ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Mariusz S. Wiglusz ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Wiesław Jerzy Cubała ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Jerzy Landowski ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Krzysztof Krysta ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland

Abstract

Background: Clozapine is the treatment of choice in drug-resistant schizophrenia. Lamotrigine is a mood stabiliser
recommended as combined treatment strategy in clozapine-resistant patients. There are cases of late-onset agranulocytosis reported
in literature. Some are associated with clozapine or lamotrigine, others with the combination of both.
Case report: The article presents a case of rapid-onset agranulocytosis in a 60-year old clozapine-resistant patient, in whom
lamotrigine was introduced as potentiation strategy. Discontinuation of both substances and GCSF treatment resulted in
normalization of the absolute neutrophil count.
Conclusions: The case suggests a possibility of developing rapid-onset agranulocytosis in clozapine-resistant patients who
require lamotrigine as augmentation strategy. This emphasises the significance of monitoring a patient's blood count and early
management of any dyscrasias noticed.

Keywords

clozapine; lamotrigine; agranulocytosis

Hrčak ID:

264590

URI

https://hrcak.srce.hr/264590

Publication date:

8.9.2015.

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