Review article

https://doi.org/10.24869/psyd.2021.283

CAESAREAN SECTION AND THE RISK OF POSTPARTAL DEPRESSION: IS THERE A POSSIBLE ROLE OF HEAT SHOCK PROTEINS?

Krunoslav Šporčić ; Department of Anaesthesiology and Intensive Care Medicine, General Hospital Vinkovci, Vinkovci, Croatia
Marko Ćaćić ; Department of Cardiology, St. Antonius Hospital Kleve, Kleve, Germany
Krešimir Reiner ; Department of Anesthesiology and Intensive Care Medicine, Clinic for Obstetrics and Gynecology, University Clinical Hospital Centre Zagreb, Zagreb, Croatia
Matko Pavlović ; Department of Psychiatry, General Hospital Bjelovar, Bjelovar, Croatia
Slobodan Mihaljević ; Department of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital Centre Zagreb, Zagreb, Croatia

Abstract

Data on the potential connection between surgical stress during caesarean section and the role of heat shock proteins in
development of postpartal depression is lacking in the literature. This is a narrative review with a goal to establish the potential role
of heat shock proteins during caesarean section and development of postpartal depression. Systemic hyperinflammatory state, such
as the one that occurs during surgery, may trigger protective cell reaction, which is usually called the heat shock response. Results of
several researches bring strong evidence of correlation between expression of genes coding for family of heat shock proteins with the
onset of depressive symptoms. Also, a recent meta-analysis established caesarean section as a risk factor for development of
postpartal depression. It is obvious that heat shock proteins play a certain role in development of psychiatric disorders. However, a
role of heat shock proteins in development of postpartal depression remains open for debate. We emphasise the need for a
randomised control trial which would enable an answer to the mentioned issue.

Keywords

heat shock proteins; caesarean section; postpartal depression

Hrčak ID:

266010

URI

https://hrcak.srce.hr/266010

Publication date:

22.11.2021.

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