Original scientific paper

https://doi.org/10.20471/acc.2021.60.03.12

99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules

Vedrana Gladić Nenadić ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ines Šiško Markoš ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Marija Punda ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ivan Blažeković ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Maja Franceschi ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ana Fröbe ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Tomislav Jukić ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

Abstract

Parathyroid scintigraphy with 99mTc-MIBI is an imaging technique used in nuclear
medicine and performed in patients with suspected hyperparathyroidism (HPT). The objective of
this study was to evaluate the role of this technique in patients who, along with suspected HPT, also
have thyroid nodules. Retrospective analysis included a period of 8 years (2006-2013). The study included
91 patients with clinical or laboratory suspected HPT. Pathologic changes in parathyroid
glands were demonstrated in 47 (70%) of 67 patients with positive scintigraphy. Pathologic changes in
parathyroid glands were not evident in the remaining 20 (30%) patients. Out of nine patients with
negative scintigraphy results but with suspected enlargement of the parathyroid gland examined by
ultrasound, eight (89%) patients did not show pathologic changes in the parathyroid gland, whereas
one (11%) patient had evident changes. Eight (54%) of 15 patients with suspected scintigraphy had
positive ultrasound findings, as well as fine needle aspiration cytology (FNAC) findings with parathyroid
hormone (PTH) determination in the aspirate. Seven (46%) patients had negative FNAC findings
and PTH in the aspirate. The study showed scintigraphy to have high sensitivity (98%) in detecting
patients with pathologic changes in the parathyroid glands. In patients with suspected HPT,
scintigraphy needs to be combined with FNAC and PTH determination in the aspirate due to its low
specificity of 28%.

Keywords

99mTc-MIBI, SPECT/CT; Hyperparathyroidism; Parathyroid hormone; Fine needle aspiration

Hrčak ID:

271450

URI

https://hrcak.srce.hr/271450

Publication date:

1.9.2021.

Article data in other languages: croatian

Visits: 3.195 *