Original scientific paper

https://doi.org/10.20471/acc.2021.60.03.18

Morphological Traits of Hepatic Parenchymal Tissue Repair Following Experimental Injury

Aleksey K. Vorontsov ; Bryansk City Hospital No. 1, Bryansk, Russian Federation
Vladislav P. Troshin ; Bryansk City Hospital No. 1, Bryansk, Russian Federation
Yuri A. Parkhisenko ; Voronezh State Medical University N. N. Burdenko, Voronezh, Russian Federation
Anton V. Korsakov ; Bryansk State Technical University, Bryansk, Russian Federation
Aleksandr V. Klimashevich ; Penza State University, Penza, Russian Federation

Abstract

The aim of the study was to investigate morphological traits of hepatic parenchymal
tissue repair in response to injury using the conventional technique (closure) and an innovation
method (such as hemostatic medication swab packing and modified batching). The experimental
study was carried out on laboratory rats of the Winzar breed using light microscopy, standard stains
for micropreparations, and morphometry. Histopathologic examination of micropreparations stained
by standard methods revealed pronounced dystrophic processes in hepatocytes located near the necrotic
zone (albuminous and hydropic degeneration and chromatin fragmentation in the nuclei).
Morphometric studies showed a significant decrease (p<0.001) in almost all indicators of the size of
cells and nuclei both near necrosis and distant from it on day 28 of the experiment in the experimental
group in comparison to the control group. The results obtained pointed to more intense repair
processes when applying the innovation method.

Keywords

Hepatic damage; Repair; Morphometry; Parenchymal tissue; Proliferation

Hrčak ID:

271644

URI

https://hrcak.srce.hr/271644

Publication date:

1.9.2021.

Article data in other languages: croatian

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