Case report
An Uncommon Presentation of Darier-White Disease with Hystrix-like Palmoplantar Keratoderma
Yakov Pessach
; Departments of Dermatology and Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Anwar Jammal
; Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Andrea Gat
; Clalit Health Care Services, Tel Aviv, Israel
Helena Martinez
; Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Eran Ellenbogen
; Departments of Dermatology and Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Eli Sprecher
; Departments of Dermatology and Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Ilan Goldberg
; Departments of Dermatology and Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Abstract
Darier-White disease is a relatively common autosomal dominant
genodermatosis caused by mutation in the ATP2A2 gene. It is characterized by
multiple warty papules coalescing into plaques in the seborrheic areas and by
specific histological skin changes. Palm and sole involvement in Darier-White
disease is usually mild, mainly featuring discrete and small keratotic papules. We
present a unique case of Darier-White disease presenting with a diffuse, mutilating
hystrix-like palmoplantar keratoderma.
Keywords
Darier-White disease, palmoplantar keratoderma, genodermatosis
Hrčak ID:
274442
URI
Publication date:
17.3.2021.
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