Original scientific paper

FOXP3 Predicts Response to Treatment in Mycosis Fungoid

Max Perelman ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Mati Rozenblat ; Department of Dermatology, Ha’emek Medical Center, Afula, Israel
Eran Ellenbogen ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Shamir Geller ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Evgenya Slutsky Bank ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Ori Eytan ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Andrea Gat ; Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Eli Sprecher ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Ilan Goldberg ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Abstract

Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein
3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of
previous studies are inconclusive.
Objective: We aimed at ascertaining the possibility that FOXP3 expression may
serve to predict MF stage and response to therapy.
Patients and methods: Immunohistochemistry staining for FOXP3 was performed
on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively
graded. Disease stage, progression, and response to treatment were determined
based on clinical and imaging evidence, and association with FOXP3 expression
was assessed.
Results: FOXP3 expression in the dermis correlated with poor response to treatment
(P=0.047). A negative non-significant relationship between epidermal FOXP3
expression and clinical stage severity was observed (P=0.17).
Conclusions: Dermal FOXP3 expression in MF lesions could be used to predict response
to treatment in patients with MF.

Keywords

MF, mycosis fungoides, CTCL, cutaneous T-cell lymphomas, Tregs, T regulatory cells, FOXP3, forkhead box P3, prognostic factor

Hrčak ID:

274452

URI

https://hrcak.srce.hr/274452

Publication date:

11.5.2021.

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