Case report

https://doi.org/10.24099/vet.arhiv.1348

The histological and immunohistochemical features of a metastatic mammary carcinosarcoma in a dog - a case report

Arda S. Tunc ; Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Diskapi, Ankara, Turkey
Arzu Taşdemir ; Department of Pathology, Kayseri City Hospital, Ministry of Health, Kocasinan/Kayseri, Turkey
Guido Rocchigiani ; Department of Veterinary Sciences, University of Pisa, Pisa, Italy
Hatice Karaman ; Department of Pathology, Kayseri City Hospital, Ministry of Health, Kocasinan/Kayseri, Turkey
Vehbi Güneş ; Department of Internal Medicine Faculty of Veterinary Medicine, Erciyes University, Melikgazi, Kayseri, Turkey
Görkem Ekebaş ; Department of Pathology, Faculty of Veterinary Medicine, Erciyes University, Melikgazi, Kayseri, Turkey
Gencay Ekinci ; Department of Internal Medicine Faculty of Veterinary Medicine, Erciyes University, Melikgazi, Kayseri, Turkey
Latife Ç. Bayram ; Department of Pathology, Faculty of Veterinary Medicine, Erciyes University, Melikgazi, Kayseri, Turkey

Abstract

A carcinosarcoma is a tumor composed of cells morphologically resembling both malignant epithelial and
mesenchymal components. An 11-year-old, female, mixed-breed terrier was referred to the clinic with complaints of
anorexia, vomiting and exercise intolerance. Clinically, tumoral masses were seen in the mammary glands. During
necropsy, multilobulated calcified masses were observed in several visceral organs (the liver, kidneys, lungs, small
intestines, lymph nodes and thyroid) and both right and left (3rd and 4th) mammary glands. Immunohistochemically,
Thyroglobulin, SMA, TTF-1, S100, CD34, and p53 were negative in both epithelial and mesenchymal areas, however,
Ki-67 showed high proliferation, especially in the mesenchymal areas. While the positivity of vimentin expression
was high in the mesenchymal component of the tumor, the positivity of cytokeratin (CK7 and CK19) expressions was
high in the epithelial component of the tumor. In the case of a carcinosarcoma, there is a probability that not only the
carcinomatous part, but also the sarcomatous part will metastasize. Despite being uncommon, canine carcinosarcomas
should always be considered in the differential diagnosis of mixed mammary tumors, if they include both components.
There have not been many previous studies dealing with the metastasis of a mammary carcinosarcoma in dogs as
an aggressive tumor. Therefore, we consider this report a worthy contribution and have defined the multiple organ
metastasis of a mammary carcinosarcoma.

Keywords

carcinosarcoma; dog; immunohistochemistry; mammary gland; metastasis

Hrčak ID:

274817

URI

https://hrcak.srce.hr/274817

Publication date:

24.3.2022.

Article data in other languages: croatian

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