Review article

Bone Metabolism in Rheumatic Diseases

Marko Barešić

Abstract

The bones that form the human skeleton are not only used to move and to protect internal organs, but also perform specific metabolic processes, of which the most important is the metabolism of calcium and phosphate. Diseases with a chronic inflammatory process in their pathogenesis (primarily inflammatory rheumatic diseases such as rheumatoid arthritis) at the level of pro-inflammatory cells, pro-inflammatory cytokines and molecules, lead to an increase in the number of osteoclasts responsible for impaired homeostasis of bone metabolism, i.e., increased resorption. Osteoimmunology is an interdisciplinary field that studies the connection between osteology and dysregulation of the immune system and immune response. Insight gained from the study of osteoimmunological mechanisms helps to better understand the loss of bone mass in pathological pro-inflammatory conditions and facilitates research into new medication that could circumvent the pro-inflammatory process.

Keywords

osteoimmunology; bone remodeling; pro-inflammatory cells; pro-inflammatory cytokines and molecules

Hrčak ID:

291552

URI

https://hrcak.srce.hr/291552

Publication date:

17.1.2023.

Article data in other languages: croatian

Visits: 620 *