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Liječnički vjesnik, Vol. 145 No. Supp 2, 2023.

Meeting abstract

https://doi.org/10.26800/LV-145-supl2-BS06

ISOSORBIDE-5-MONONITRATE INDUCED PERIPHERAL AND CENTRAL VASCULAR DYSFUNCTION IN RATS AND TRETMENT WITH STABLE GASTRIC PENTADECAPEPTIDE BPC 157

Vlasta Vuković ; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Vraneš
Luka Kalogjera

Full text: english pdf 244 Kb

page 43-43

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Abstract

Introduction: Although the understanding of migraine pathophysiology is incomplete, it is now well accepted that this neurovascular syndrome is
mainly due to cranial vasodilation. Several experimental migraine models have been developed, including the use of a nitric oxide (NO) donor, such as isosorbide-5-mononitrate (IS-5-MN). Nitric oxide regulates cerebral and extracerebral cranial blood flow and arterial diameters. We observed the therapeutic effects of stable gastric pentadecapeptide BPC 157 on peripheral and central vascular dysfunction caused by IS-5- MN administration .

Keywords

BPC157; IS-5-MN; migraine; pharmacology; vascular dysfunction

Hrčak ID:

303006

URI

https://hrcak.srce.hr/303006

Publication date:

23.4.2023.

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