Original scientific paper

https://doi.org/10.21860/medflum2023_306355

Clinical Characteristics and Predictors Affecting the Probability of Complications and Negative Outcome in Hospitalized Patients with Influenza

Luka Švitek ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet, Osijek, Hrvatska
Dario Sabadi ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet, Osijek, Hrvatska
Ilija Rubil ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet, Osijek, Hrvatska
Mario Duvnjak ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet, Osijek, Hrvatska
Dubravka Lišnjić orcid.org/0009-0009-8612-0241 ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet, Osijek, Hrvatska

Abstract

Aim: The main objective of the study is to examine clinical characteristics in relation to age and complications, and to find predictors that affect the likelihood of complications and the negative outcome in hospitalized patients with influenza. Respondents and methods: The study included all hospitalized patients with clinically and/or laboratory-proven influenza at the Clinic for Infectious Diseases of the Clinical Hospital Center Osijek in the period from December 2018 to April 2019. The survey was conducted on 128 respondents. Clinical, demographic, microbiological, radiological, biochemical, and hematological data were collected and analyzed from the History of the disease. Results: Research has shown that higher age is associated with a more severe form of the clinical picture of influenza and a complicated course of the disease. Urea with a value of more than 9.2 mmol / L and an age higher than 78 years proved to be useful as predictors of the negative outcome, and female sex and CRP with a resolution point of more than 128.9 mg / L as predictors of the presence of pneumonia. Complications are generally more common in patients with a longer clinical course of the disease and higher values of inflammatory parameters when admitted to the hospital. Conclusion: The results of the study indicate the undisputed severity of the clinical picture, the level of laboratory disorders, the occurrence of complications, and the impact of age and comorbidity in patients with influenza. Further systematic monitoring of patients and prospective studies are needed to finally define specific early predictors of the severity of the clinical picture, for the purpose of timely and effective treatment and a more favorable disease outcome.

Keywords

Comorbidity; Influenza, Human; Pneumonia; Respiratory Tract Infections; Viruses

Hrčak ID:

306355

URI

https://hrcak.srce.hr/306355

Publication date:

1.9.2023.

Article data in other languages: croatian

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