Original scientific paper

https://doi.org/10.5562/cca4021

Thia-Michael Addition in Diverse Organic Synthesis

Sachin A. Khiste ; Department of Chemistry, Vaishanvi Mahavidyalaya of Wadvani-431144, Maharashtra, India
Deepali S. Pakhare ; Department of Microbiology, Tuljaram Chaturchand College, Baramati-413102, Maharashtra, India
Vijaykumar S. More ; Department of Chemistry, Kai. Rasika Mahavidyalaya Deoni-413519, Maharashtra, India
Guravaiah Chakibanda ; Department of Chemistry, Aavvaiyar Government College for women, Karaikal, Pondicherry-609602 India
Mahendra N. Lokhande ; Department of Chemistry, Aavvaiyar Government College for women, Karaikal, Pondicherry-609602 India

Abstract

Thia-Michael addition reactions are significant for organic syntheses of important class of compounds to form C-S bond and its derivatives. It shows the prominent feature in medicinal field and material science. This review is focused on various methods towards thia-Michael adducts using Michael addition of sulfur containing electron rich species (Michael donor) on electron poor olefins (Michael acceptor). The C-S bond is ideal of making bioactive molecules generalized for the synthesis of various drug molecules and applied in field as insect sprays and polymer substances which are common for daily life. Due to the importance of C-S bond in recent years, novel methods for C-S bond formation were developed, which are more convenient with environment.

Keywords

Thia-Michael addition; catalyst; Michael donor; organo-sulfur compounds

Hrčak ID:

312163

URI

https://hrcak.srce.hr/312163

Publication date:

10.12.2023.

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