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Rad Croatian Academy of Sciences and Arts. Medical sciences : Medical Sciences, Vol. 559 No. 64-65, 2023.

Original scientific paper

https://doi.org/10.21857/ypn4ocd1v9

Arterial stiffness in prehypertensive patients with white coat hypertension

Juraj Jug orcid id orcid.org/0000-0002-3189-1518 ; Health center Zagreb West, Zagreb, Croatia *
Điđi Delalić ; Emergency Internal Medicine Clinic, Clinical Hospital Merkur, Zagreb, Croatia
Ingrid Prkačin ; Emergency Internal Medicine Clinic, Clinical Hospital Merkur, Zagreb, Croatia

* Corresponding author.

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Abstract

Introduction: White-coat hypertension (WCH) is associated with higher cardiovascular risk and increased all-cause mortality in the general population. The aim of this study was to determine whether there are differences in primary laboratory findings and pulse wave velocity (PWV) between prehypertensive patients with and without WCH.
Materials and Methods: This study included healthy 62 patients (37 women, 25 men) with prehypertension without medication based on ambulatory blood pressure monitoring [ABPM]) from one family practice in Health center Zagreb-West. Patients were divided into two groups depending on having WCH (>20 mmHg difference from in office SBP from average ABPM SBP values). Basic laboratory, anthropometric, 24h ambulatory blood pressure, and pulse wave velocity (PWV) measurements were done in all patients. Mann-Whitney U test, Kruskal-Wallis’s test and descriptive statistics were used in data processing in Statistica v.12.0.
Results: WCH was found in 11 patients (17,7 %). Prehypertensive patients with WCH had significantly higher fasting glucose (median 5.7 [5.0–5.8] vs 5.3 [5.4–6.1] mmol/L;p < 0.001) and higher PWV (median 8.1 [7.1-8.8] vs. 9.0 [8.3–10.0] m/s; p=0.008). Patients with WCH had higher PWV in all three examined age groups (40–49 years p=0,074; 50-59 years p=0,003; 60-70 years p < 0,001). No differences were found in the concentration of potassium, LDL cholesterol, triglycerides, and body mass index (median 25.6kg/m2).
Conclusion: This pilot study indicates the possible existence of accelerated atherosclerosis in prehypertensive individuals with WCH. It is necessary to conduct research on a larger sample to confirm these findings.

Keywords

Cardiometabolic risk factors; Vascular stiffness; White coat hypertension

Hrčak ID:

312650

URI

https://hrcak.srce.hr/312650

Publication date:

22.12.2023.

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