Short communication, Note

https://doi.org/10.2478/v10007-008-0029-9

Characterization of ternary complexes of meloxicam-HPbCD and PVP or L-arginine prepared by the spray-drying technique

HODA A. EL-MARADNY ; Department of Industrial Pharmacy, Faculty of Pharmacy, University of Alexandria
SANA A. MORTADA ; Department of Industrial Pharmacy, Faculty of Pharmacy, University of Alexandria
OLA A. KAMEL ; Amriya Pharmaceutical Industry, Alexandria, Egypt
AHMED H. HIKAL ; Amriya Pharmaceutical Industry, Alexandria, Egypt

Abstract

Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-b-cyclodextrin (HPbCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary systems of ME-HPCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPCD. Tablets compressed from ternary system of ME-HPCD-L-argininewere compared with plain and commercial tablets. Phase solubility experiments suggested the formation of inclusion complex of AL type. Ternary system of ME-HPbCD-L-arginine exhibited a stability constant 30.3 times higher than the binary system of ME-HPbCD, while the ternary system of ME-HPbCD-PVP increased the stability constant 2.2 times only. The prepared complexes were characterized by scanning electron microscopy, differential scanning calorimetry and infra red spectroscopy. Ternary solid complexes indicated the presence of strong interactions between the components. The dissolution behaviour of ME from different ternary complexes was higher than its dissolution from the binary system. Tablets compressed from ternary complexes of ME-HPbCD-L-arginine highly improved drug release compared to plain and commercial tablets.

Keywords

meloxicam; hydroxypropyl-b-cyclodextrin; polyvinyl pyrrolidone; L-arginine; spray-drying technique

Hrčak ID:

28922

URI

https://hrcak.srce.hr/28922

Publication date:

1.12.2008.

Article data in other languages: croatian

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