Original scientific paper

https://doi.org/10.20471/acc.2023.62.03.6

Study Hypothesis: Age, Gender, Presence of Diabetes Mellitus or Hypertension, and Anti-Hypertensive Drugs Are Independent Risk Factors for COVID-19 Mortality

Faruk Karandere orcid.org/0000-0002-7423-0170 ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Internal Medicine, Istanbul, Turkey *
Hakan Kocoglu ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Ramazan Korkusuz ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey
Betul Erismis ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Mehmet Hursitoglu ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Internal Medicine, Istanbul, Turkey
Kadriye Yasar Kart ; Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey

* Corresponding author.

Abstract

We aimed to investigate the effects of comorbid diseases and antihypertensive
drugs on the clinical outcome of hospitalized patients with COVID-19 infection. A total of 1045
patients whose data could be gathered and confirmed from both hospital files and Turkish National
Health Network records were retrospectively screened, and 264 of 1045 patients were excluded
because of having more than one comorbid disease. The study population consisted of a total of 781
patients, of which 482 had no comorbid disease, while the remaining 299 patients had only one
comorbid disease. The mortality risk was 7.532 times higher in those over 65 years of age compared
to cases younger than 30 years (OR: 7.532; 95% CI: 1.733-32.730); the risk of mortality in men
was 2.131 times higher than in women (OR: 2.131; 95% CI: 1.230-3.693); and presence of diabetes
mellitus (DM) increased mortality risk 2.784 times (OR: 2.784; 95% CI: 1.288-6.019). While
hypertension was not found to be an independent risk factor for COVID-19 mortality, age, gender,
and presence of DM were independent risk factors for COVID-19 mortality. There was no association
between antihypertensive drugs and mortality. Accordingly, age (>65 years), gender (male), and
presence of DM were independent risk factors for COVID-19 mortality, whereas hypertension and
use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and their combinations
with other antihypertensive drugs were not risk factors for COVID-19 mortality.

Keywords

COVID-19; Hypertension; Diabetes mellitus; Angiotensin-converting enzyme inhibitor; Angiotensin II receptor blocker

Hrčak ID:

314861

URI

https://hrcak.srce.hr/314861

Publication date:

1.11.2023.

Article data in other languages: croatian

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