Review article
https://doi.org/10.26800/LV-146-supl1-16
Infant with hypogammaglobulinemia
Marta Navratil
Abstract
Infants with recurrent respiratory infections are a common problem in everyday pediatric practice, which is due to the unclear definition of a healthy infant, possible serious underlying diseases, and complex diagnostic work-up that often requires consultation with a pediatric allergist and clinical immunologist. Symptoms and clinical signs are often insufficient to make a correct diagnosis, and immunoglobulin levels vary by age with a wide range of normal values. Differential diagnosis, symptomatic hypogammaglobulinemia in infants can be an early manifestation of primary immunodeficiency, a consequence of delayed maturation of normal immunoglobulin production, a consequence of immunoglobulin loss due to another disease or iatrogenically suppressed production. The aim of this work is to give the primary pediatrician an overview of the possible causes of hypogammaglobulinemia in infancy and to help solve diagnostic doubts, and especially to recognize cases of primary immunodeficiency and secondary hypogammaglobulinemia that require further processing and treatment.
Keywords
INFANT; HYPOGAMMAGLOBULINEMIA; IMMUNOGLOBULINS; PRIMARY IMMUNODEFICIENCIES
Hrčak ID:
315830
URI
Publication date:
11.4.2024.
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