Medicina Fluminensis, Vol. 60 No. 2, 2024.
Original scientific paper
https://doi.org/10.21860/medflum2024_316191
Red Cell Distribution Width and Platelet Indices as Inflammatory Parameters in Type 2 Diabetic Patients with Kidney Dysfunction
Almir Fajkić
orcid.org/0000-0002-3722-9701
; University of Sarajevo, Faculty of Medicine, Department of Pathophysiology, Sarajevo, Bosnia and Herzegovina
*
Rijad Jahić
; General Hospital “Prim. Dr. Abdulah Nakas”, Sarajevo, Bosnia and Herzegovina
Avdo Kurtović
; Clinical Center University of Tuzla, Tuzla, Bosnia and Herzegovina
Lamija Mlačo
; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
Amela Dervišević
; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
Hana Bašić
; University of Sarajevo, Faculty of Medicine, Sarajevo, Bosnia and Herzegovina
Layan Mattar
; University of Sarajevo, Faculty of Medicine, Sarajevo, Bosnia and Herzegovina
Fatka Kovačević
; University of Sarajevo, Faculty of Medicine, Sarajevo, Bosnia and Herzegovina
Khelle Lama
; University of Sarajevo, Faculty of Medicine, Sarajevo, Bosnia and Herzegovina
Malik Ejubović
; Cantonal Hospital Zenica, Department of Internal Medicine, Zenica, Bosnia and Herzegovina
Orhan Lepara
; University of Sarajevo, Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina
* Corresponding author.
Abstract
Aim: To assess Red blood cell Distribution Width (RDW) and platelet indices values in patients with type 2 diabetes mellitus (T2DM) and to verify its association with kidney dysfunction (KD). Patients and Methods: A cross-sectional study included 149 T2DM subjects divided into two groups with (T2DM – KD; n=52) and without (T2DM-nKD; n=97) presence of kidney dysfunction and 30 healthy subjects. White Blood Cells (WBC) count, C-reactive protein (CRP), fibrinogen, RDW, platelet indices, urea, and creatinine, were measured in all participants. Kidney function was evaluated by the estimated glomerular filtration rate (eGFR) calculated using the simplified Modification of Diet in Renal Disease (MDRD) formula. Results: T2DM-KD subjects showed statistically significantly higher values of the parameters RDW (p<0.01), Mean Platelet Volume - MPV (p<0.01), Platelet Distribution Width-PDW (p<0.01), Platelecrit-PCT (p<0.01), and Platelet Mass Index-PMI (p<0.01) compared to T2DM-nKD subjects, and statistically significantly lower values of the WBC count in T2DM-KD subjects compared to subjects suffering from T2DM without kidney dysfunction (p<0.01). ROC curve analysis revealed that RDW (sensitivity of 80.8%, specificity of 78.3%), MPV (sensitivity of 75%, specificity of 78.4 %), and PDW (sensitivity of 80.8%, specificity of 83.5%) could be used as markers in distinguishing between T2DM subjects with and without kidney dysfunction. Conclusion: This study confirms the reliability of the RDW,MPV, and PDW as simple, low cost and useful markers in distinguishing between T2DM subjects with and without kidney dysfunction.
Keywords
blood platelets; diabetes mellitus, type 2; erythrocytes; renal insufficiency
Hrčak ID:
316191
URI
Publication date:
1.6.2024.
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