Skip to the main content

Original scientific paper

https://doi.org/10.2478/aiht-2024-75-3826

The effects of iron oxide nanoparticles on antioxidant capacity and response to oxidative stress in Mozambique tilapia (Oreochromis mossambicus, Peters 1852)

Puthan Variyam Vidya Balakrishnan ; University of Calicut, Department of Zoology, Endocrinology and Toxicology Laboratory, Malappuram, India
Goran Gajski ; Institute for Medical Research and Occupational Health, Division of Toxicology, Zagreb, Croatia
Kumari Chidambaran Chitra ; University of Calicut, Department of Zoology, Endocrinology and Toxicology Laboratory, Malappuram, India


Full text: english pdf 1.710 Kb

versions

page 125-136

downloads: 0

cite


Abstract

Recent research has raised concern about the biocompatibility of iron oxide nanoparticles (IONPs), as they have been reported to induce oxidative stress and inflammatory responses, whilst prolonged exposure to high IONP concentrations may lead to cyto-/genotoxicity. Besides, there is concern about its environmental impact. The aim of our study was to investigate the effects of IONPs on the antioxidant defence system in freshwater fish Mozambique tilapia (Oreochromis mossambicus, Peters 1852). The fish were exposed to IONP concentration of 15 mg/L over 1, 3, 4, 15, 30, and 60 days and the findings compared to a control, unexposed group. In addition, we followed up the fish for 60 days after exposure had stopped to estimate the stability of oxidative stress induced by IONPs. Exposure affected the activity of antioxidant and marker enzymes and increased the levels of hydrogen peroxide and lipid peroxidation in the gill, liver, and brain tissues of the fish. Even after 60 days of depuration, adverse effects remained, indicating long-term nanotoxicity. Moreover, IONPs accumulated in the gill, liver, and brain tissues. Our findings underscore the potential health risks posed to non-target organisms in the environment, and it is imperative to establish appropriate guidelines for safe handling and disposal of IONPs to protect the aquatic environment.

Keywords

antioxidant enzymes; bioaccumulation; environmental health; oxidative stress; toxicity

Hrčak ID:

318100

URI

https://hrcak.srce.hr/318100

Publication date:

19.6.2024.

Article data in other languages: croatian

Visits: 0 *