Acta clinica Croatica, Vol. 63. No. 1, 2024.
Original scientific paper
https://doi.org/10.20471/acc.2024.63.01.6
Eosinophilic granulomatosis with polyangiitis induced by montelukast
Paul Grama
; George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, First Internal Medical Department, Târgu Mureș, Romania
Corina Ureche
; George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, First Internal Medical Department, Târgu Mureș, Romania
*
Corina Adelina Zah
; Dr. Carol Davila Central Military Emergency Hospital, Radiology Department, Bucharest, Romania
Anca Dana Buzoianu
; Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania
Ioana Corina Bocsan
; Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania
* Corresponding author.
Abstract
Leukotriene receptor antagonists are a class of drugs used in maintenance therapy
of asthma. Among the adverse effects induced by them, particularly by montelukast, is eosinophilic
granulomatosis with polyangiitis (EGPA), which manifests as a form of vasculitis co-occurring with
severe asthma and eosinophilia. Our aim was to point to the importance of this particular diagnosis by
analyzing the published cases of montelukast induced EGPA and to analyze them in order to identify
if this form of EGPA presented some specific characteristics. Leukotriene receptor antagonist induced
EGPA is a frequent adverse event compared to EGPA induced by other drugs, and specialists should
be aware of it. We observed that more than half of patients were female. Montelukast induced EGPA
occurred after a variable period of time. The most common clinical manifestation was neuropathy and
most of the patients had a good outcome after immunosuppressant treatment. The present diagnosis
should be considered by physicians when patients are prescribed montelukast followed by worsening
of symptoms.
Keywords
Eosinophilic granulomatosis with polyangiitis; Eosinophilia; Montelukast; Asthma
Hrčak ID:
322024
URI
Publication date:
1.4.2024.
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