Review article

https://doi.org/10.46419/vs.56.4.8

Cabergoline versus Bromocriptine for oestrus induction in female dogs

Rédha Belala ; Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Medicine, Saad Dahleb Blida University 1, Blida, Algeria, Biotechnologies Platform for Animal Medicine & Reproduction (BIOMERA)
Seddik Kebbal ; Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Medicine, Saad Dahleb Blida University 1, Blida, Algeria, Biotechnologies Platform for Animal Medicine & Reproduction (BIOMERA)
Rachid Kaidi ; Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Medicine, Saad Dahleb Blida University 1, Blida, Algeria, Biotechnologies Platform for Animal Medicine & Reproduction (BIOMERA), Saad Dahleb Blida University 1, Algeria, Animal Health and Production Laboratory (SPA), Higher National Veterinary School of Algiers, Algeria
Nora Mimoune orcid.org/0000-0002-0900-3908 ; Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Medicine, Saad Dahleb Blida University 1, Blida, Algeria, Biotechnologies Platform for Animal Medicine & Reproduction (BIOMERA), Saad Dahleb Blida University 1, Algeria, Animal Health and Production Laboratory (SPA), Higher National Veterinary School of Algiers, Algeria *

* Corresponding author.

Abstract

This study aimed to evaluate two protocols
of oestrus induction, using different anti-prolac-
tin dopamine agonists (cabergoline, bromocrip-
tine) in domestic bitches. For this purpose, 16
females previously followed were divided into
two experimental groups: Group A, bromocrip-
tine induction group (n=8; 0.05 mg/kg/day/oral-
ly) and group B, cabergoline treatment group
(n=8; 0.005 mg/kg/day/orally). Comparison of
the effects of the two substances included several
parameters (oestrus induction, pregnancy, and
whelping rates, litter size, treatment duration,
shortening of inter-oestrus interval, and effect
on duration of the inter-oestrus interval follow-
ing the induced cycle). Cabergoline was more
efficient than bromocriptine with induction,
pregnancy and whelping rates of 87.5% versus
25%, respectively (P<0.05). The mean duration of
cabergoline treatment was 24.43 ± 7.77 days with
a range from 16.66 to 32.20 days, as opposed to
a duration of 34.50 ± 6.86 days and range from
27.64 to 41.36 days for bromocriptine. Moreover,
cabergoline reduced the inter-oestrus interval
in normal cycled bitches by a mean duration of
43.40 ± 14.30 days and a range from 29.10 to 57.70
days, while no significant shortening of this in-
terval was observed with bromocriptine. For lit-
ter size, no significant difference was observed
between values before and after induction treat-
ments. Neither drug significantly affected the
inter-oestrus interval after the induced cycle. Ca-
bergoline treatment was therefore more effective
and safer than bromocriptine for inducing fertile
oestrus in domestic bitches followed by normal
pregnancy, whelping and litter size and also a
normal post induction inter-oestrus interval. It
also has an easier administration protocol and
fewer side effects. In addition, cabergoline was
more efficient in inducing oestrus in females
with a long inter-oestrus and in those presenting
primary and secondary anoestrus with no extra
gonadal causes.

Keywords

bitch; treatment; cabergoline; bro- mocriptine; oestrus cycle

Hrčak ID:

322610

URI

https://hrcak.srce.hr/322610

Publication date:

26.1.2025.

Article data in other languages: croatian

Visits: 108 *