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Croatian Medical Journal, Vol. 65 No. 2, 2024.

Original scientific paper

https://doi.org/10.3325/cmj.2024.65.138

Factors contributing to variability in metformin concentration in polycystic ovary syndrome

Valentina N. Nikolić ; Department of Pharmacology with Toxicology, University of Niš Faculty of Medicine, Niš, Serbia *
Milan Stefanović ; Department of Gynaecology and Obstetrics, University of Niš Faculty of Medicine, Niš, Serbia
Dejan Mitić ; Department of Gynaecology and Obstetrics, University of Niš Faculty of Medicine, Niš, Serbia
Slavica Sunarić ; Department of Chemistry, University of Niš Faculty of Medicine, Niš, Serbia
Maša Jović ; Department of Pharmacy, University of Niš Faculty of Medicine, Niš, Serbia
Aleksandra Ignjatović ; Department of Medical Statistics and Informatics, University of Niš Faculty of Medicine, Niš, Serbia
Dragana Stokanović ; Department of Pharmacology with Toxicology, University of Niš Faculty of Medicine, Niš, Serbia

* Corresponding author.

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page 138-145

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Abstract

Aim To investigate the factors affecting metformin concentrations after chronic administration in patients with
polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for personalized therapy.
Methods This study enrolled 53 PCOS patients undergoing long-term metformin treatment at the Clinic for Gynecology and Obstetrics in Niš, Serbia, from February to
December 2019. Pharmacokinetic parameters were measured from blood samples, and metformin concentrations
were determined with validated analytical techniques.
Results There was a significant variability in metformin
concentrations among PCOS patients, with body mass index (BMI) identified as a major influencing factor. Higher
BMI was associated with lower plasma metformin levels, a
finding suggesting an altered pharmacokinetic profile in
obese patients.
Conclusions This study highlights the critical role of BMI in
influencing metformin pharmacokinetics in PCOS patients
and underscores the need for personalized treatment strategies in patients with PCOS.

Keywords

Hrčak ID:

331945

URI

https://hrcak.srce.hr/331945

Publication date:

30.4.2024.

Visits: 188 *