Letter to the Editor
The role of proteomics in the discovery of new anti cancer drugs
Sandra Kraljević Pavelić
; Laboratory for systemic biomedicine, Division of molecular medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Nina Šaban
; Laboratory for systemic biomedicine, Division of molecular medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Abstract
The fi eld of proteomics has been thought as complementary to the genomic research since proteins are the executi ve molecules and players in biological systems. In particular, protein functionality is highly deregulated in cancer. Although proteomics is a relatively new research area it holds great potential in pharmaceutical industry due to its ability to quantitatively measure protein expression and identi fy proteins by mass spectrometry analyses as well as its ability to map the protein-protein interacti ons. As such, the proteomics
technological platf orm has been widely applied to basic cancer research, cancer therapy and most importantly in the drug discovery process. Proteomics allows identi fi cati on of proteins involved in cancer pathogenesis and deregulated signalling pathways that facilitates the discovery of new drug targets, or it might be used as well to precisely elucidate the drug mechanisms of acti on and toxicology.
Keywords
anti cancer drugs; cancer; proteomics
Hrčak ID:
43662
URI
Publication date:
1.9.2009.
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