Review article
Unveiling the mechanisms of breast cancer pathogenesis by proteomics methods
Ivana Ratkaj
; Division of molecular medicine, Laboratory for systemic biomedicine, Rudjer Boskovic Institute, Zagreb, Croatia
Sandra Kraljević Pavelić
; Department of biotechnology, University of Rijeka, Rijeka, Croatia
Abstract
Breast cancer is a complex and heterogenic disease. Classical molecular medical
approaches cannot be successfully used to completely understand its pathogenesis. In additi
on, fi nding new biological markers that would help in early detecti on and creati on of guided
and specifi c therapy is crucial for the future breast cancer management. The results of
breast cancer research in combinati on with those obtained by large scale methods that examine
the expression status of genes and proteins, have pointed to an important molecule,
namely the human growth hormone (hGH), as a major player in the pathogenesis of breast
cancer. It acts through the autocrine regulati on system where the acti vati on of Pax-5 gene
has been recently confi rmed as well. A large number of new biomarkers, like HOXA1, CHOP
SH3GLB1, casein kinase, p53, annexin XI, CDC25C, eIF-4E, MAP kinase 7, 14-3-3e, galecti n-1,
annexin-5, annexin-1, LDH-B, GST-pi, acti n, vimenti n, HSP70, CK18, moesin, SH3GLB1, SUB1,
SND1 i TRIM28, osteoponti n and osteonecti n, have been recently identi fi ed as well.
Keywords
breast cancer; molecular medicine; protein profile; proteomics
Hrčak ID:
43669
URI
Publication date:
1.9.2009.
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