Original scientific paper

The pharmacokinetics of cefepime in E. coli lipopolysaccharide induced febrile buffalo calves

Bharat Joshi ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Suresh Kumar Sharma ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India

Abstract

The pharmacokinetics of cefepime after its single intravenous administration (10 mg/kg) was
investigated in experimentally induced fever in buffalo calves (n = 4). The fever was induced by single/repeated intravenous injection of E. coli lipopolysaccaride (1 μg/kg). The drug was estimated in plasma samples by microbiological assay using E. coli (MTCC 739) test organism. The pharmacokinetic behaviour of cefepime in febrile animals was described by a two compartment open model. At 1 min, the concentration of cefepime in plasma was 40.8 ± 0.98 μg/mL which rapidly declined to 23.0 ± 0.64 μg/mL at 15 min. The drug was detected up to 24 h. The elimination half-life and volume of distribution were 3.00 ± 0.18 h and 0.42 ± 0.02 L/kg, respectively. The distribution half-life, AUC and total body clearance (ClB) were
0.08 ± 0.002 h, 101 ± 7.65 μg/mL.h and 98.8 ± 6.06 mL/kg/h, respectively. To maintain a minimum therapeutic concentration of 1 μg/mL, a satisfactory dosage regimen of cefepime in febrile buffalo calves would be 7 mg/kg repeated at 12 h intervals.

Keywords

buffalo calf; cefepime; dosage regimen; fever; pharmacokinetics

Hrčak ID:

48219

URI

https://hrcak.srce.hr/48219

Publication date:

18.12.2009.

Article data in other languages: croatian

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