Meeting abstract

INFECTION OR IDIOSYNCRATIC REACTION TO ANTIEPILEPTIC DRUGS?

Paola Presečki ; Psychiatric Hospital Sveti Ivan, Jankomir 11, Zagreb, Croatia
Vlado Grošić ; Psychiatric Hospital Sveti Ivan, Jankomir 11, Zagreb, Croatia
Ante Silić ; Psychiatric Hospital Sveti Ivan, Jankomir 11, Zagreb, Croatia
Mate Mihanović ; Psychiatric Hospital Sveti Ivan, Jankomir 11, Zagreb, Croatia

Abstract

Idiosyncratic reactions are serious, unpredicted adverse effects of antiepileptic drugs which are in use in psychiatry as mood
stabilizers. Severe idiosyncratic reactions can manifest as systemic symptoms or Dress syndrome clinically manifested with
increased body temperature, peripheral lymphadenopathy and potential one or multiple organ failure.
We present a 36 years old patient, who was hospitalized for the first time in our hospital after he attempted suicide by hanging.
Patient was diagnosed as Bipolar affective disorder, current episode depressive with psychotic features and high suicidal risk. At the
time of admission he was taking olanzapine and venlafaxine. Psychopharmacs were cross titrated to clozapine, valproic acid and
lamotrigine. Two weeks later, patient’s mood was stabilized but his somatic status worsened dramatically. He was forwarded to
Clinic for Infective Diseases where he was diagnosed with severe sepsis. Dress syndrome, although initially suspected was not
verified, but has to be taken into consideration in each patient prescribed with antiepileptic drugs.

Keywords

antiepileptic drugs; dress syndrome; idiosyncratic reactions; infection

Hrčak ID:

48668

URI

https://hrcak.srce.hr/48668

Publication date:

10.2.2010.

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